In this episode, Curtis examines the rise of game theory used during the Cold War and the way in which its mathematical models of human behavior filtered into economic thought.
The program traces the development of game theory with particular reference to the work of John Nash (famous from "Beautiful Mind"), who believed that all humans were inherently suspicious and selfish creatures that strategized constantly. Using this as his first premise, Nash constructed logically consistent and mathematically verifiable models, for which he won the Nobel Prize in Economics. He invented system games reflecting his beliefs about human behavior, including one called "So Long Sucker---F*ck Your Buddy", in which the only way to win was to betray your playing partner, and it is from this game that the episode's title is taken. These games were internally coherent and worked correctly as long as the players obeyed the ground rules that they should behave selfishly and try to outwit their opponents, but when RAND's analysts tried the games on their own secretaries, they instead chose not to betray each other, but to cooperate every time. This did not, in the eyes of the analysts, discredit the models, but instead proved that the secretaries were unfit subjects.